The last time it could have made a difference was when the eldest child of Queen Victoria was a female - Victoria, Princess Royal who later became Empress Frederick of Germany and Queen of Prussia. She was the mother of Kaiser Wilhelm II.

Had she been the heir it is possible that that she would have married differently than she did and produced different offspring than she did.

But she would only have outlived her mother by just over five months, dying on August 5th 1901.

Ah, the ifs of history!