Back when I was volunteer at the Smithsonian Institute's Insect Zoo, I had a pet Mexican Red-Kneed Tarantula, name Rosie. (Her water bottle was an empty half-pint of tequila.) Their poison (and the poison of other tarantulas) is no worse than a bee or wasp, so its not a problem unless you are allergic. The real issue is their fangs are like the prongs of a very large fork VV Ouch.

The mature male out on its final prowl for a mate can be identified by small hook like appendages that it grows under its front legs. They use these to hook the females fangs to keep her from biting them.

Best regards,

Jake